RTA 744_product_DataBase

Bioactivity	RTA 744 (WP 744) is a Doxorubicin (HY-15142A) analogue. RTA 744 triggers apoptosis and cell killing in NB cells by activating proapoptotic mediators. RTA 744 has proapoptotic and anti-leukemia activities. RTA 744 can be used for cancer research[1][2][3].
Invitro	WP 769 hydrochloride 抑制 K562 细胞的活性，IC50 值为 0.18 mg/mL[1]。WP 769 hydrochloride (0-100 µM；24 h) 抑制 KBM-5 细胞吸收胸腺嘧啶[2]。WP 769 hydrochloride (1 µM；15 min) 在 KBM-5 细胞中通过 NF-κB 的 p50 和 p65 亚基激活 NF-κB[2]。WP 769 hydrochloride (0-100 µM；72 h) 以剂量依赖性方式抑制 Jurkat 和 RIP 缺失的 Jurkat 细胞增值[2]。 Cell Viability Assay[2] Cell Line:
Name	RTA 744
CAS	293736-67-1
Formula	C34H36ClNO11
Molar Mass	670.10
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Faderl S, et al. WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res. 2001 Nov-Dec;21(6A):3777-84. [2]. Ashikawa K, et al. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol. 2004 Jan 15;67(2):353-64. [3]. Wu J, Harris NL, Inge TH. Nuclear factor-kappa B and apoptosis inducing factor activation by doxorubicin analog WP744 in SH-SY5Y neuroblastoma cells. J Surg Res. 2004 Dec;122(2):231-9.

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