RS-18286_product_DataBase

Bioactivity	RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback[1].
CAS	109458-76-6
Sequence	Ac-{d-Phe<Cl>}-{d-Phe<Cl>}-{d-Trp}-Ser-Tyr-{d-Har<Et,Et>}-Leu-Arg-Pro-{d-Ala}
Shortening	Ac-{d-Phe<Cl>}-{d-Phe<Cl>}-{d-Trp}-SY-{d-Har<Et,Et>}-LRP-{d-Ala}
Formula	C74H101Cl2N17O14
Molar Mass	1523.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lincoln GA, et al. Compensatory response of the luteinizing-hormone (LH)-releasing hormone (LHRH)/LH pulse generator after administration of a potent LHRH antagonist in the ram. Endocrinology. 1987 Jun;120(6):2245-50.

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