| Bioactivity | ROS tracer precursor is the precursor of [18F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis[1]. |
| In Vivo | [18F]ROStrace is a radiotracer for imaging superoxide in vivo with positron emission tomography (PET), in an LPS model of neuroinflammation. [18F]ROStrace is found to rapidly cross the blood-brain barrier (BBB) and is trapped in the brain of LPS-treated animals. [18F]ox-ROStrace, the oxidized form of [18F]ROStrace, does not cross the BBB. [18F]ROStrace is a suitable radiotracer for imaging superoxide levels in the central nervous system with PET[1]. |
| Name | ROS tracer precursor |
| CAS | 2153480-20-5 |
| Formula | C39H45N3O8S |
| Molar Mass | 715.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hou C, et al. Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. |