| Bioactivity | Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2]. | ||||||||||||
| Invitro | Quisqualic acid is an agonist of AMPA and metabotropic glutamate receptors. Quisqualic acid activates mGluR2R (EC50=108 μM; Ki=113 μM) and mGluR4R (EC50=593 μM; Ki=112 μM)[1]. | ||||||||||||
| Name | Quisqualic acid | ||||||||||||
| CAS | 52809-07-1 | ||||||||||||
| Formula | C5H7N3O5 | ||||||||||||
| Molar Mass | 189.13 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [2]. H Bräuner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. |
Quisqualic acid
CAS: 52809-07-1 F: C5H7N3O5 W: 189.13
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of
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