| Bioactivity | Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2]. |
| Invitro | Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines[2].Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)[2].Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs[2]. Western Blot Analysis[2] Cell Line: |
| In Vivo | Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo[1]. Animal Model: |
| Name | Quinagolide hydrochloride |
| CAS | 94424-50-7 |
| Formula | C20H34ClN3O3S |
| Molar Mass | 432.02 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Trouillas J, et al. Inhibitory effects of the dopamine agonists quinagolide (CV 205-502) and bromocriptine on prolactin secretion and growth of SMtTW pituitary tumors in the rat. Endocrinology. 1994 Jan;134(1):401-10. [2]. Iampietro C, et al. Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Feb 4;23(3):1775. |
Quinagolide hydrochloride
CAS: 94424-50-7 F: C20H34ClN3O3S W: 432.02
Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quina
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