| Bioactivity | Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3]. |
| Invitro | Quinacrine mustard dihydrochloride (5 µg/ml) can be used for the DNA strain of plant, animal, or human chromosomes[1].Quinacrine mustard dihydrochloride (28 µM) increases the number ofmutants that appeared after an exposure of bacteria[2].quinacrine mustard dihydrochloride (0.2 µM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells[3].Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 µM; 4h) in HL-60 cells[3]. Cell Cycle Analysis[3] Cell Line: |
| Name | Quinacrine mustard dihydrochloride |
| CAS | 4213-45-0 |
| Formula | C23H30Cl5N3O |
| Molar Mass | 541.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762. [2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57. [3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34. |
Quinacrine mustard dihydrochloride
CAS: 4213-45-0 F: C23H30Cl5N3O W: 541.77
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent
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