| Bioactivity | Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2]. |
| Invitro | Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells[2].Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions[1].Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells[1]. |
| Name | Pseudocoptisine acetate |
| CAS | 30426-66-5 |
| Formula | C21H17NO6 |
| Molar Mass | 379.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Pseudocoptisine acetate
CAS: 30426-66-5 F: C21H17NO6 W: 379.36
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Cory
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