Protoporphyrin IX disodium

CAS: 50865-01-5 F: C34H32N4Na2O4 W: 606.62

Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitize

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Bioactivity	Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma[1][2][3][4][5].
Invitro	Protoporphyrin IX disodium (3.6 nmol/g 组织) 组织在光照下能引起正常大鼠结肠黏膜坏死[4]。Protoporphyrin IX disodium (6.6 nmol/g 肿瘤) 在大鼠肿瘤辐照后延缓肿瘤生长[4]。Protoporphyrin IX disodium (0-25 μM, 2 小时) 迅速导致 Hela 细胞中核 G4 水平升高[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Protoporphyrin IX disodium 相关抗体:
In Vivo	Aminolevulinic acid (300 mg/kg, 单次静脉注射) 给药 3 小时后，大鼠肝脏和肠道中 Protoporphyrin IX disodium 含量最高 (约 6.3 nmol/g 组织)，其次是主动脉 (4.3 nmol/g 组织) 和食道 (2.1 nmol/g 组织)[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	50865-01-5
Formula	C34H32N4Na2O4
Molar Mass	606.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yasushi Nakai, et al.Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer. [2]. Myrzakhmetov B, et al. Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin® in Different Conditions. Pharmaceuticals (Basel). 2021 Feb 9;14(2):138. [3]. Tope WD, et al. Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid[J]. Photochem Photobiol. 1998 Feb;67(2):249-55. [4]. van den Boogert J, et al. 5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration[J]. J Photochem Photobiol B. 1998 Jun 15;44(1):29-38. [5]. Li C, et al. G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes. Genome Biol. 2022 Dec 15;23(1):259.

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