| Bioactivity | Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis; has also been tested for use in the treatment of leprosy.Target: Anti tuberculosisAlthough ETH and PTH are both potent drugs against M. tuberculosis (MIC = ～0.5 μg/ml) (24), they do not affect E. coli growth, even at very high concentrations (100 μg/ml), which is primarily caused by the absence of an EthA homologue in E. coli [1]. Clinical improvement was noted in 74% of the patients treated with ethionamide and in 83% of those treated with prothionamide. Therapy was well tolerated and drug-related hepatotoxicity did not require discontinuation of therapy. The 500-mg dose of both ethionamide and prothionamide resulted in loss in Mycobacterium leprae viability more rapidly than did the 250-mg dose, and prothionamide at both dose levels was superior to the equivalent dose of ethionamide [2]. | ||||||||||||
| Name | Prothionamide | ||||||||||||
| CAS | 14222-60-7 | ||||||||||||
| Formula | C9H12N2S | ||||||||||||
| Molar Mass | 180.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Prothionamide
CAS: 14222-60-7 F: C9H12N2S W: 180.27
Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis; has also been tested for use in the tre
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