| Bioactivity | Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis[1]. | ||||||
| Invitro | Proteasome-activating peptide 1 (TFA) (0-100 μM, 2 h) increases ChT-L catalytic activity of the 20S proteasome in a dose-dependent manner[1].Proteasome-activating peptide 1 (TFA) (50 μM, 24 h) induces the degradation of SOD1, promotes a decrease of oxidized proteins[1]. Proteasome-activating peptide 1 (TFA) (0-100 μM) protects fibroblast and SH-SY5Y cells from oxidative stress[1].Proteasome-activating peptide 1 (TFA) only affects the free 20S proteasomal pool[1]. Proteasome-activating peptide 1 (TFA) promotes proteasomal gate opening[1]. Cell Viability Assay Cell Line: | ||||||
| Name | Proteasome-activating peptide 1 TFA | ||||||
| Shortening | IPRCRKMPGVKMC-NH2 | ||||||
| Formula | C65H117F3N22O15S4 | ||||||
| Molar Mass | 1632.02 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Proteasome-activating peptide 1 TFA
CAS: F: C65H117F3N22O15S4 W: 1632.02
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA
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