| Bioactivity | Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. | ||||||||||||
| Invitro | Propranolol (10-7 M-10-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10-5 M in HemSCs[4].Propranolol (10-9 M-10-3 M; 24 and 48 hours) significant decreases cell proliferation at 10-4 M propranolol after 24 hours and 10-9 M propranolol after 48 hours in HemSCs[4].Propranolol (50 μM-200 μM；24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis[4]. Western Blot Analysis[4] Cell Line: | ||||||||||||
| Name | Propranolol | ||||||||||||
| CAS | 525-66-6 | ||||||||||||
| Formula | C16H21NO2 | ||||||||||||
| Molar Mass | 259.34 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|