| Bioactivity | Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia[1][2]. |
| In Vivo | Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4].Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5]. |
| Name | Propiomazine |
| CAS | 362-29-8 |
| Formula | C20H24N2OS |
| Molar Mass | 340.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. [2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. [3]. C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224. [4]. F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87(1):46-51. [5]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. |