Propargylcholine bromide_product_DataBase

Bioactivity	Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells[1][2].
Invitro	Propargylcholine bromide (10, 50 µM; 24 h) 掺入 NIH 3T3细胞中，并以浓度依赖性方式显示强染色 (用 Alexa568 叠氮化物固定并染色)[1]。 Immunofluorescence[1] Cell Line:
In Vivo	Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) 在恒河猴中给药后 1 周内有效掺入新合成的髓磷脂并持续存在超过 6 周[2]。
Name	Propargylcholine bromide
CAS	111755-76-1
Formula	C7H14BrNO
Molar Mass	208.10
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jao CY, et al. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15332-7. [2]. Karen R. Bottenfield, et al. Optimization of Propargylcholine to Label Newly Synthesized Myelin in the Rhesus Monkey Brain. FASEB J. 2020, 34(S1): 1-1.

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