Procyanidin C1_product_DataBase

Bioactivity	Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice[1][2].
Invitro	Procyanidin C1 (6.25-100 μg/mL; 48 h) shows cytotoxic activities to MCF-7 and MDA-MB-231 cells[1].Procyanidin C1 (35 μg/mL; 48 h) affects cell cycle of MCF-7 and MDA-MB-231 cancer cells[1].Procyanidin C1 significantly up-regulates Chk 1 and Chk 2 in MCF-7 and MDA-MB-231 cancer cells[1].Procyanidin C1 (27.85 and 66.41 μL) induces significant DNA damage in MCF-7 and MDA-MB-231 cancer cells[1].Procyanidin C1 (45 μg/mL; 72 h) reduces the expression level of Bcl-2 but increases the expression level of BAX, and increases activities of caspase 3 and 9 to induces cell apoptosis of MCF-7 and MDA-MB-231 cancer cells[1]. Cell Cycle Analysis[1] Cell Line:
Name	Procyanidin C1
CAS	37064-30-5
Formula	C45H38O18
Molar Mass	866.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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