| Bioactivity | Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor[1]. |
| Name | Proadrenomedullin (1-20), human |
| CAS | 150238-87-2 |
| Sequence | Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 |
| Shortening | ARLDVASEFRKKWNKWALSR-NH2 |
| Formula | C112H178N36O27 |
| Molar Mass | 2460.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16. |
Proadrenomedullin (1-20), human
CAS: 150238-87-2 F: C112H178N36O27 W: 2460.84
Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chro
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