| Bioactivity | Polysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. | ||||||||||||
| Invitro | Addition of Polysorbate 20 can modify lignin surface properties to change its hydrophobicity, hydrogen bonding ability and surface charges, thus reducing the non-productive adsorption of proteins[1]. Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml, while its effect in lower pH or in water was much smaller (20 μg/ml in pH 4.5). The increased concentration of phosphate salts (0.2 mol/l) at pH 6.5 in the presence of 0.7% of polysorbate 20, resulted in further increase of candesartan cilexetil solubility to 620 μg/ml[2]. | ||||||||||||
| Name | Polysorbate 20 | ||||||||||||
| CAS | 9005-64-5 | ||||||||||||
| Appearance | Viscous liquid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yu-An Chen, et al. Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure. Bioresour Technol. 2018 Dec;269:329-338. [2]. Katarzyna Hoppe, et al. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25. [3]. JustynaŁuczak, et al. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37. |