Polyinosinic acid_product_DataBase

Bioactivity	Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1].
Invitro	Polyinosinic acid (50 µg/mL；24 h) 诱导 BALB/c B 细胞中 CD86、CD40 和 MHC II 的表达，BALB/c BMDC 细胞中 CD86 和 CD40 的表达[1]。Polyinosinic acid (1、5 和 25 µg/mL；48 h) 以剂量依赖性方式加强了 BALB/c B 细胞对 [3H] 胸苷的摄取[1]。Polyinosinic acid (50 µg/mL；20 h) 诱导 BALB/c BMDC 细胞和巨噬细胞分泌 TNFα 和 IL-12，BALB/c B 细胞、BMDC 细胞分泌 IFN。Polyinosinic acid 增加了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞中 MHC II、CD86 的表达[1]。Polyinosinic acid (50 µg/mL；48 h) 加强了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞对胸苷的摄取[1]。Polyinosinic acid (25 µg/mL 和 50 µg/mL；24 h) 以剂量依赖性方式诱导 BEAS-2B 细胞分泌 IP-10[1]。Polyinosinic acid (50 µg/mL；24 h 或 48 h) 通过 TRIF 调节 TRIF+/+ 和 TRIF-/- 小鼠 B 细胞中 CD86 的表达及胸苷的摄取[1]。Polyinosinic acid (10、20 或 50 µg/mL；20 h) 增加了 TLR3+/+ 来源的 BMDC 细胞分泌 IFN 和 IFNα，但不影响 TLR3-/- 来源的 BMDC 细胞[1]。
Name	Polyinosinic acid
CAS	30918-54-8
Formula	(C10H13N4O8P)x
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Marshall-Clarke S, et al. Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem. 2007 Aug 24;282(34):24759-66.

PeptideDB

Polyinosinic acid

CAS: 30918-54-8 F: (C10H13N4O8P)x W: