| Bioactivity | Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule[1]. |
| In Vivo | Poly(styrenyl acetal trehalose) (10 mg/kg; IV, single dosage) does not induce liver or kidney damage, and is safe in terms of acute toxicity in mice[1].Poly(styrenyl acetal trehalose) (1 mg/kg; IP, twice, at the 0 and 14 day) does not induce the increase of pro-inflammatory cytokines and IgG[1]. Animal Model: |
| Name | Poly(styrenyl acetal trehalose) |
| Formula | C23H34O11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ko JH, et al. Safety and Biodistribution Profile of Poly(styrenyl acetal trehalose) and Its Granulocyte Colony Stimulating Factor Conjugate. Biomacromolecules. 2022 Jun 29. |
Poly(styrenyl acetal trehalose)
CAS: F: C23H34O11 W:
Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals
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