| Bioactivity | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia[1][2]. |
| In Vivo | Plasminogen (plg) (2 mg/per; i.v.; single daily for 16 days) accelerates the healing of burn wounds in WT mice[1].Plasminogen (plg) (2 mg/per; i.v.; single daily for 16 days) enhances the expression of IL-6 and augments the activation of STAT3 in wounded skin of both WT and plg-deficient mice[1].Plasminogen (plg) (2 mg/per; i.v.; single daily for 24 days) improves the healing of burn wounds in a mouse model of diabetes[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 9001-91-6 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shen Y, et al. Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood. 2012 Jun 14;119(24):5879-87. [2]. Keragala CB, et al. Plasminogen: an enigmatic zymogen. Blood. 2021 May 27;137(21):2881-2889. |