| Bioactivity | Plasmin is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells[1][2]. |
| Invitro | Plasmin (20 μg/mL, 24 h) can activate PAR-1, strongly induce ERK phosphorylation, and degrade e-cadherin in mouse cortical tubular epithelial cell line (MCT)[1]. |
| Name | Plasmin |
| CAS | 9001-90-5 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guoqiang Zhang, et al. Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals. J Am Soc Nephrol. 2007 Mar;18(3):846-59. [2]. Dominik F Draxler, et al. Plasmin: A Modulator of Immune Function. Semin Thromb Hemost. 2017 Mar;43(2):143-153. |