Pirenzepine dihydrochloride_product_DataBase

Bioactivity	Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells[1][2].
Invitro	Pirenzepine (100-140 μg/mL; 24 h) inhibits PC-3 cell proliferation activity[2].Pirenzepine (110 μg/mL; 24 h) inhibits prostate and lung cancer cell migration[2].Pirenzepine (100-130 μg/mL; 0-24 h) inhibits the expression of GLI1 in PC-3 cells[2]. Cell Proliferation Assay[2] Cell Line:
In Vivo	Pirenzepine (intraperitoneal injection; 0.3 mg/kg; once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock[3]. Animal Model:
Name	Pirenzepine dihydrochloride
CAS	29868-97-1
Formula	C19H23Cl2N5O2
Molar Mass	424.32
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Carmine AA, et al. Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. Drugs. 1985 Aug;30(2):85-126. [2]. Yin QQ, et al. Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling. Asian J Androl. 2018 Nov-Dec;20(6):608-614. [3]. Yabuki Y, et al. The T-type calcium channel enhancer SAK3 inhibits neuronal death following transient brain ischemia via nicotinic acetylcholine receptor stimulation. Neurochem Int. 2017 Sep;108:272-281.

PeptideDB

Pirenzepine dihydrochloride

CAS: 29868-97-1 F: C19H23Cl2N5O2 W: 424.32