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Pilsicainide hydrochloride

CAS: 88069-49-2 F: C17H25ClN2O W: 308.85

Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agen
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Bioactivity Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent[1][2].
Invitro Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].
In Vivo Pilsicainide hydrochloride (SUN-1165) (2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1]. Animal Model:
Name Pilsicainide hydrochloride
CAS 88069-49-2
Formula C17H25ClN2O
Molar Mass 308.85
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Yamakawa M, et al. Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats. Thyroid. 2005 Jul;15(7):653-9. [2]. Plosker GL. Pilsicainide. Drugs. 2010 Mar 5;70(4):455-67.