| Bioactivity | Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR[1][2]. Picrotoxin (Cocculin) causes overstimulation and induces convulsions[2]. | ||||||||||||
| In Vivo | Picrotoxin (1.0 mg/kg, i.p. once a day for 5 days) acts as a GABAA receptor antagonist, and increased the number of ligodendrocyte progenitor cells (OPCs) pairs in NG2-CreERTM:EYFP mice[1]. Animal Model: | ||||||||||||
| Name | Picrotoxin | ||||||||||||
| CAS | 124-87-8 | ||||||||||||
| Formula | C30H34O13 | ||||||||||||
| Molar Mass | 602.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Boulanger JJ, et al. Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis. Neuroscience. 2017 Aug 18. pii: S0306-4522(17)30584-5. [2]. Carpenter TS, et al. Identification of a possible secondary picrotoxin-binding site on the GABA(A) receptor. Chem Res Toxicol. 2013 Oct 21;26(10):1444-54. |