| Bioactivity | Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs/b> with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission[1][2]. | |||||||||
| Target | IC50: 13.1 μM (α2 GlyRs) | |||||||||
| Invitro | Picrotin has sensitivity for α2 GlyRs with IC50 value of 13.1 μM[1]. | |||||||||
| Name | Picrotin | |||||||||
| CAS | 21416-53-5 | |||||||||
| Formula | C15H18O7 | |||||||||
| Molar Mass | 310.30 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. [2]. Dian-Shi Wang, et al. Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem. 2007 Jun 1;282(22):16016-35. |