| Bioactivity | Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2]. |
| Invitro | Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM[1].Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL)[2]. Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2]. Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3]. |
| Name | Pendulone |
| CAS | 69359-09-7 |
| Formula | C17H16O6 |
| Molar Mass | 316.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |