| Bioactivity | Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3]. | ||||||||||||
| Invitro | Panobinosta (LBH589) induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta treatment results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells[1]. Panobinostat exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50 ranging from 5 to 100 nM[2]. | ||||||||||||
| Name | Panobinostat | ||||||||||||
| CAS | 404950-80-7 | ||||||||||||
| Formula | C21H23N3O2 | ||||||||||||
| Molar Mass | 349.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Panobinostat
CAS: 404950-80-7 F: C21H23N3O2 W: 349.43
Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic act
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.