Pamoic acid disodium_product_DataBase

Bioactivity	Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].
Target	EC50: 79 nM (GPR35), 65 nM (ERK1/2)
Invitro	Pamoic acid (0.1 nM-0.1 mM) induces GPR35a internalization with an EC50 value of 22 nM[1].Pamoic acid (0-10 μM) induces ERK1/2 activation[1]. Western Blot Analysis[1] Cell Line:
In Vivo	Pamoic acid disodium (0-100 mg/kg; s.c.; once) induces a dose-related antinociception in the abdominal constriction test[1]. Animal Model:
Name	Pamoic acid disodium
CAS	6640-22-8
Formula	C23H14Na2O6
Molar Mass	432.33
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.

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