| Bioactivity | Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1]. |
| Invitro | Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells[1]. Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: |
| Name | Paeonoside |
| CAS | 20309-70-0 |
| Formula | C15H20O8 |
| Molar Mass | 328.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kyung-Ran Park, et al. Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules. Int J Mol Sci. 2021 Jun 27;22(13):6899. |