| Bioactivity | PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2]. | |||||||||
| Target | IC50: 8 μM (PTP1B) | |||||||||
| Invitro | PTP1B-IN-4 (250 µM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1].PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1]. Western Blot Analysis[1] Cell Line: | |||||||||
| Name | PTP1B-IN-4 | |||||||||
| CAS | 765317-72-4 | |||||||||
| Formula | C26H19Br2N3O7S3 | |||||||||
| Molar Mass | 741.45 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11(8), 730–737. [2]. Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6(1). |
PTP1B-IN-4
CAS: 765317-72-4 F: C26H19Br2N3O7S3 W: 741.45
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. P
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