| Bioactivity | POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts[1]. | ||||||||||||
| Invitro | When POBN (20 mM) and Sodium formate (100 mM) are mixed in the collecting tube with bile in the presence of 2,2′-dipyridyl (DP) (5 mM) and bathocuproinedisulfonic acid disodium salt hydrate (BC) (5 mM), only a minor residual signal of POBN radical adduct is observed[1]. | ||||||||||||
| In Vivo | Electron spin resonance (ESR) spectrum of radical adducts detected in bile of rats 1 h after acute Sodium formate (2 g/kg) and POBN (1.5 g/kg) i.p. administration[1]. Animal Model: | ||||||||||||
| Name | POBN | ||||||||||||
| CAS | 66893-81-0 | ||||||||||||
| Formula | C10H14N2O2 | ||||||||||||
| Molar Mass | 194.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. A E Dikalova, et al. An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53. |