| Bioactivity | PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for drugs, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3]. | ||||||||||||
| Invitro | PLGA (75:25) (0.03-5 mg/mL; 72 h) only affects the viability of Calu-3 cells at concentrations that are too high for clinical use[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| In Vivo | PLGA (75:25) (40 mg/kg Risperidone (PLGA (75:25) as a drug delivery carrier); s.c.; single) shows a good activity of sustained drug release for 45 days[2]. Animal Model: | ||||||||||||
| Name | PLGA (75:25) | ||||||||||||
| CAS | 34346-01-5 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Mura S, et al. Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells. Int J Nanomedicine. 2011;6:2591-605. [2]. D'Souza S, et al. Development of Risperidone PLGA Microspheres. J Drug Deliv. 2014;2014:620464. [3]. Makadia HK, et al. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers (Basel). 2011 Sep 1;3(3):1377-1397. |