Bioactivity | PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM. | ||||||||||||
Invitro | PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ[1]. | ||||||||||||
In Vivo | PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss[1]. | ||||||||||||
Name | PI-3065 | ||||||||||||
CAS | 955977-50-1 | ||||||||||||
Formula | C27H31FN6OS | ||||||||||||
Molar Mass | 506.64 | ||||||||||||
Appearance | Solid | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
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Reference | [1]. Ali K, et al. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;509(7505):407-11. |