| Bioactivity | PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1]. | ||||||
| Invitro | Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN[2].PEN binds and activates a GPCR in the brain[2]. | ||||||
| Name | PEN (human) | ||||||
| CAS | 597578-70-6 | ||||||
| Shortening | AADHDVGSELPPEGVLGALLRV | ||||||
| Formula | C97H159N27O32 | ||||||
| Molar Mass | 2215.46 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. [2]. Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43. |
PEN (human)
CAS: 597578-70-6 F: C97H159N27O32 W: 2215.46
PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenou
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