| Bioactivity | PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM. | ||||||||||||
| Target | Ki: 1.2±0.4 nM(AhR) | ||||||||||||
| Invitro | PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1]. | ||||||||||||
| Name | PDM2 | ||||||||||||
| CAS | 688348-25-6 | ||||||||||||
| Formula | C14H9Cl3 | ||||||||||||
| Molar Mass | 283.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. |