| Bioactivity | PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1]. |
| Invitro | PD-L1-IN-3 (Compound 4a) (0.01-100 μM, 40分钟) 破坏 PD-1 和 PD-L1 之间的结合，增强 TCR 介导的 Jurkat 细胞活化[1]。PD-L1-IN-3 (0.01-100, 40分钟)在 PD-L1+ 在 H358 肿瘤中有较高的摄取，其摄取与 PD-L1 表达相关[1]。 0 --> PD-L1-IN-3 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | Animal Model: |
| Name | PD-L1-IN-3 |
| Formula | C19H16ClFN2OS |
| Molar Mass | 374.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ważyńska MA, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023 Jul 27;66(14):9577-9591. |