| Bioactivity | PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2]. |
| Target | IC50: formyl peptide receptor 2 (FPR2) |
| Name | PBP10 |
| CAS | 794466-43-6 |
| Sequence | RhB-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH |
| Shortening | RhB-QRLFQVKGRR-OH |
| Formula | C84H127N24O15 |
| Molar Mass | 1713.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem [2]. Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22. |
PBP10
CAS: 794466-43-6 F: C84H127N24O15 W: 1713.06
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1
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