| Bioactivity | PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research[1][2][3]. | ||||||
| Invitro | PACAP-38 (31-38), human, mouse, rat (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2 and ERK tyrosine phosphorylation[1].PACAP-38 (31-38), human, mouse, rat (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%[1].PACAP-38 (31-38), human, mouse, rat (10 nM; 48 h) stimulates the growth of NCI-H838 cells[1].PACAP-38 (31-38), human, mouse, rat (300 nM; 4 h) stimulates generation of APPsα in neural cells[2].PACAP-38 (31-38), human, mouse, rat (0.01-10 nM; HEK 293 cells) stimulates neural cells express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM[2].PACAP-38 (31-38), human, mouse, rat (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures[3].PACAP-38 (31-38), human, mouse, rat (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons[3]. Cell Viability Assay[1] Cell Line: | ||||||
| Name | PACAP-38 (31-38), human, mouse, rat | ||||||
| CAS | 138764-85-9 | ||||||
| Sequence | Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 | ||||||
| Shortening | YKQRVKNK-NH2 | ||||||
| Formula | C47H83N17O11 | ||||||
| Molar Mass | 1062.27 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017. [2]. Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. [3]. Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 De |
PACAP-38 (31-38), human, mouse, rat
CAS: 138764-85-9 F: C47H83N17O11 W: 1062.27
PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-3
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