| Bioactivity | Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1]. |
| Invitro | Oxprenolol is lipophilic[3].Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin[3]. |
| In Vivo | Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range[2]. Animal Model: |
| Name | Oxprenolol |
| CAS | 6452-71-7 |
| Formula | C15H23NO3 |
| Molar Mass | 265.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T Nagatomo, et al. Binding Characteristics of 3H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [3]. Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259. |