Oxiconazole_product_DataBase

Bioactivity	Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3].
Invitro	Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1].Antifungal Activities of Oxiconazole[1].
In Vivo	Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3]. Animal Model:
Name	Oxiconazole
CAS	64211-45-6
Formula	C18H13Cl4N3O
Molar Mass	429.13
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rossello A, et al. Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45(22):4903-12. [2]. Svecova L, et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48. [3]. Shi J, et al. Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest. Int J Biol Sci. 2022 May 21;18(9):3747-3761.

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