| Bioactivity | Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues[1]. | ||||||||||||
| Invitro | Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM[1].Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons[1].Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1[1]. | ||||||||||||
| In Vivo | Optovin (1-10 μM) causes light-dependent motor excitation in vivo[1].Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice[1].Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish[1]. | ||||||||||||
| Name | Optovin | ||||||||||||
| CAS | 348575-88-2 | ||||||||||||
| Formula | C15H13N3OS2 | ||||||||||||
| Molar Mass | 315.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63. |