ORC-13661 hydrochloride_product_DataBase

Bioactivity	ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker[1].
Invitro	ORC-13661 (0.10-8.3 μM；野生型 *AB 斑马鱼毛细胞) hydrochloride 保护斑马鱼毛细胞免受多种氨基糖苷类 (AG) 的影响[1]。ORC-13661 (0.10-20 μM) hydrochloride 保护斑马鱼侧线毛细胞和哺乳动物毛细胞免受 Cisplatin (HY-17394) 影响[1]。ORC-13661 (0.3 and 3 μM) hydrochloride 是听觉毛细胞 MET 通道的可逆阻断剂。ORC-13661 hydrochloride 阻断 OHC MET 电流。ORC-13661 hydrochloride MET 通道块具有电压依赖性和渗透性[1]。
In Vivo	ORC-13661 (0.2-5 mg/kg; 口服; 每日一次, 持续 10 天) hydrochloride 以剂量依赖性方式保护大鼠的听力免受阿米卡星的影响[1]。 Animal Model:
Name	ORC-13661 hydrochloride
CAS	1589571-77-6
Formula	C18H20Cl2N4O2S
Molar Mass	427.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kitcher SR, et, al. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764.

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