Nα,Nα-Bis(carboxymethyl)-L-lysine_product_DataBase

Bioactivity

Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

Invitro

Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM)使 H214A (T2R4 的组成型活性突变体) 的基础活性降低 40%[1]。Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 分钟) 可以阻断过表达 T2R4 和 Ga16/44 的 HEK293T细胞中奎宁引起的 Rac1 基础活化状态的降低，但在 HEK293T 野生型细胞中没有这种阻断作用[2]。 0 --> Nα,Nα-Bis(carboxymethyl)-L-lysine 相关抗体:

In Vivo

Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) 在成年 C57BL6/J 中对苦味物质的舔舐反应无影响[3]。

Name

Nα,Nα-Bis(carboxymethyl)-L-lysine

CAS

113231-05-3

Formula

C10H18N2O6

Molar Mass

262.26

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289(36):25054-25066. [2]. Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426(1-2):129-136. [3]. Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.

PeptideDB

Nα,Nα-Bis(carboxymethyl)-L-lysine

CAS: 113231-05-3 F: C10H18N2O6 W: 262.26