| Bioactivity | Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties. |
| Invitro | The main urine metabolites of racemic zopiclone are the less active eszopiclone-N-oxide (RP 29753) and the inactive Norzopiclone (N-desmethyleszopiclone, RP 32273)[1]. Zopiclone has two major metabolites, N-oxideZopiclone and Norzopiclone (N-desmethyl-Zopiclone). N-oxideZopiclone has a hypnotic activity lower than the parent Zopiclone, whereas Norzopiclone (N-desmethyl-Zopiclone) lacks hypnotic effect, but has some anxiolytic properties[3]. |
| In Vivo | A demethylation metabolic pathway produces Norzopiclone (N-desmethylzopiclone), a metabolite which reportedly accounts for 15% of an oral dose of racemic Zopiclone, and which is also reportedly inactive[2]. N-oxide-Zopiclone has a similar t1/2 compared to parent Zopiclone, while the t1/2 of Norzopiclone (N-desmethyl-Zopiclone) ranges from 7 to 11 h[3]. |
| Name | Norzopiclone |
| CAS | 59878-63-6 |
| Formula | C16H15ClN6O3 |
| Molar Mass | 374.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21. [2]. Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1. [3]. Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62(8):645-51. |