Nizofenone_product_DataBase

Bioactivity	Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3].
Invitro	Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3].Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3].Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3].Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4].
In Vivo	Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments[1].Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2]. Animal Model:
Name	Nizofenone
CAS	54533-85-6
Formula	C21H21ClN4O3
Molar Mass	412.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. [2]. Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262(1-2):157-61. [3]. Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. [4]. H Yasuda, et al. Cerebral protective effect and radical scavenging action. J Neurochem. 1981 Oct;37(4):934-8.

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Nizofenone

CAS: 54533-85-6 F: C21H21ClN4O3 W: 412.87