| Bioactivity | Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells[1]. | ||||||||||||
| Invitro | Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects[1].Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker)[1].Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2[1].Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells[1].Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | Neuropathiazol | ||||||||||||
| CAS | 880090-88-0 | ||||||||||||
| Formula | C19H18N2O2S | ||||||||||||
| Molar Mass | 338.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Warashina M, et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16;45(4):591-3. |
Neuropathiazol
CAS: 880090-88-0 F: C19H18N2O2S W: 338.42
Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocam
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