| Bioactivity | Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation. | ||||||||||||
| Invitro | Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid[1]. | ||||||||||||
| Name | Neochlorogenic acid | ||||||||||||
| CAS | 906-33-2 | ||||||||||||
| Formula | C16H18O9 | ||||||||||||
| Molar Mass | 354.31 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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Neochlorogenic acid
CAS: 906-33-2 F: C16H18O9 W: 354.31
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants.Neochlorogenic acid inhibi
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