| Bioactivity | Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6[1]. | ||||||||||||
| Target | Nav1.1. | ||||||||||||
| In Vivo | Nav1.1 activator 1 (compound 4) is a valuable Nav1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome[1]. Animal Model: | ||||||||||||
| Name | Nav1.1 activator 1 | ||||||||||||
| CAS | 2332897-85-3 | ||||||||||||
| Formula | C24H23F3N4O | ||||||||||||
| Molar Mass | 440.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Miyazaki T, et al. Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators. Bioorg Med Chem Lett. 2019 Mar 15;29(6):815-820. |
Nav1.1 activator 1
CAS: 2332897-85-3 F: C24H23F3N4O W: 440.46
Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (t
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