NF-κΒ activator 2_product_DataBase

Bioactivity

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

Invitro

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1].

In Vivo

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1].

Name

NF-κΒ activator 2

CAS

2375281-44-8

Formula

C16H11FN2O3

Molar Mass

298.27

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.

PeptideDB

NF-κΒ activator 2

CAS: 2375281-44-8 F: C16H11FN2O3 W: 298.27