| Bioactivity | NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2]. |
| Invitro | NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。NAADP tetrasodium (10 μM，30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。 |
| In Vivo | NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: |
| Name | NAADP |
| CAS | 5502-96-5 |
| Formula | C21H27N6O18P3 |
| Molar Mass | 744.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. [2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7. [3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137. |