| Bioactivity | Muscarine ((+)-Muscarine) is a toxin that can stimulate the parasympathetic nervous system. Muscarine is an agonist of muscarinic acetylcholine receptor (mAChR)[1][2]. |
| Invitro | 在脑微血管内皮细胞和小鼠脑微血管内皮细胞中，Muscarine (100 µM) 诱导的细胞内钙信号振幅与 10 µM 乙酰胆碱触发的信号振幅相似[1]。Muscarine (1-30 μM；2 分钟) 在中缝大核 (NRM) 神经元上含有 5-羟色胺 (5-HT) 的 NRM 细胞亚群中产生剂量依赖性超极化，EC50 值为 2.7 µM[2]。 |
| Name | Muscarine |
| CAS | 300-54-9 |
| Formula | C9H20NO2+ |
| Molar Mass | 174.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083. [2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8. |